A Review on “Modification of intra-bone marrow bone marrow transplantation: aiming for better bone marrow transplantation methods”

We have developed a powerful bone marrow transplantation method, intra-bone marrow-bone marrow transplantation (IBM-BMT), in which donor BM cells (BMCs) are directly injected into the recipient’s BM, resulting in a rapid recovery of donor hematopoiesis and a reduction in the severity of GVHD. We subsequently developed more effective BMT protocols by modifying IBM-BMT. One method involves the simultaneous injection of BMCs and bone marrow stromal cells into the recipient’s bone marrow cavity. Another involves the retention of the injected BMCs in the recipient’s bone marrow cavity using collagen gel or magnetic beads plus a magnet. The last method is IBM-BMT using an inhibitor of apoptosis. These methods accelerate the hematopoiesis of donor bone marrow cells.